Thursday, March 28, 2013

Just 'weight' until menopause: How estrogen deficiency affects women's fat absorption

Mar. 27, 2013 ? Women tend to carry excess fat in their hips and thighs, while men tend to carry it on their stomachs. But after menopause, things start to change: many women's fat storage patterns start to resemble those of men. This indicates that there's a link between estrogen and body fat storage. This connection is well documented, but the underlying mechanisms remained poorly understood until now.

New research conducted by Sylvia Santosa, assistant professor in Concordia University's Department of Exercise Science and Canada Research Chair in Clinical Nutrition, gives us a new look at the connection between fat storage and estrogen. By examining the fat storage process at a cellular level, Santosa and co-author Michael D. Jensen of the Mayo Clinic in Rochester, Minnesota, reveal that certain proteins and enzymes are more active in post-menopausal women. These proteins correspond with fat storage. Their findings were published in the March 2013 issue of Diabetes.

"The fat stored on our hips and thighs, is relatively harmless," explains Santosa, who is also a member of Concordia's PERFORM Centre for better health through prevention. "But the fat stored around the abdomen is more dangerous. It has been associated with diabetes, heart disease, stroke and even some cancers. When post-menopausal women put on more abdominal fat, they dramatically increase their risk for these health problems. Given these dangers, it is very important to understand the how the lower levels of estrogen associated with menopause changes where fat is stored."

Santosa's research compared fat storage in pre- and post-menopausal women. The 23 women who participated in the study were in the same age range, and had similar Body Mass Indices and body fat composition. These similarities allowed Santosa to isolate the effects of estrogen on fat absorption and storage.

She and Jensen were able to examine the activity of certain enzymes and proteins that regulate fat storage in post-menopausal women's abdomens and thighs. By considering these factors together rather than in isolation, the researchers determined conclusively that the overall fat storage "machinery" is more active in post-menopausal women. In other words, these cells now store more fat than they did before menopause.

In addition, post-menopausal women burned less fat than their pre-menopausal colleagues. These changes mean that their cells are not only storing more fat, but are also less willing to part with it. This combination is a recipe for rapid weight gain. "Taken together, these changes in bodily processes may be more than a little surprising -- and upsetting -- for women who previously had little trouble managing their weight," comments Santosa.

Though the increased cellular activity revealed by this study was not specific to the abdominal region, more fat stored overall means more abdominal fat. Evidence of changes in the fat storage pathways after menopause is an important contribution to understanding why post-menopausal women begin to put on more visceral fat.

Says Santosa, "the information revealed by our study is valuable not only to post-menopausal women and their doctors, but to obesity studies more generally. A clearer picture of which proteins and enzymes increase fat storage makes those productive targets for future medical advances in the fight against obesity."

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Concordia University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. S. Santosa, M. D. Jensen. Adipocyte Fatty Acid Storage Factors Enhance Subcutaneous Fat Storage in Postmenopausal Women. Diabetes, 2012; 62 (3): 775 DOI: 10.2337/db12-0912

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/XZtpEFjYZwo/130327144131.htm

Christmas Abbott clive davis nba trade thomas robinson nba trades ign Xbox 720

Amazon Acquires Social Reading Site Goodreads, Which Gives The Company A Social Advantage Over Apple

Goodreads-LogoToday, Amazon has announced the acquisition of social reading service, Goodreads. Specific terms of the deal weren’t disclosed and it should close by the end of Q2. Goodreads had raised $2.75 million in funding from the likes of True Ventures since launching in January 2007. When we talked to them last August, the site had over 10 million members and had catalogued more than 360 million books, adding 22 million each month. Now, the site boasts over 16 million users. This type of social integration could give Amazon a major advantage over e-sellers like Apple, who have no social components to their product whatsoever. With people actually discussing and sharing the books that they’re into, having an Amazon direct connect makes complete sense. The site can offer special deals to Goodreads users, which in essence is now Amazon’s book-reading social network. Here’s a look at the spike in books added per month in a graph from last August. With a connection to Kindle, those numbers will skyrocket: Amazon VP of Kindle content, Russ Grandinetti discussed how important this integration could be for its e-book division: Amazon and Goodreads share a passion for reinventing reading. Goodreads has helped change how we discover and discuss books and, with Kindle, Amazon has helped expand reading around the world. In addition, both Amazon and Goodreads have helped thousands of authors reach a wider audience and make a better living at their craft. Together we intend to build many new ways to delight readers and authors alike. Goodreads’ CEO and co-founder Otis Chandler discussed the acquisition and the opportunity for the site to infuse some social elements into Amazon’s bookselling strategy: Books ? and the stories and ideas captured inside them ? are part of our social fabric. People love to talk about ideas and share their passion for the stories they read. I?m incredibly excited about the opportunity to partner with Amazon and Kindle. We?re now going to be able to move faster in bringing the Goodreads experience to millions of readers around the world. We?re looking forward to inspiring greater literary discussion and helping more readers find great books, whether they read in print or digitally. Goodreads has also posted its own note on its blog, going a bit deeper into why the deal makes sense and making it clear that Kindle integration is a top priority, as it’s something that users had

Source: http://feedproxy.google.com/~r/Techcrunch/~3/fR3EbmF81M0/

viktor bout ncaa hockey role models ferdinand porsche gregg williams theraflu masters leaderboard

40 years on, Vietnam troop withdrawal remembered

FILE - In this March 29, 1973 file photo, the American flag is furled at a ceremony marking official deactivation of the Military Assistance Command-Vietnam (MACV) in Saigon, after more than 11 years in South Vietnam. While the fall of Saigon in 1975 ? with its indelible images of frantic helicopter evacuations ? is remembered as the final day of the Vietnam War, March 29 marks an anniversary that holds greater meaning for many who fought, protested or otherwise lived the war. (AP Photo/Charles Harrity, File)

FILE - In this March 29, 1973 file photo, the American flag is furled at a ceremony marking official deactivation of the Military Assistance Command-Vietnam (MACV) in Saigon, after more than 11 years in South Vietnam. While the fall of Saigon in 1975 ? with its indelible images of frantic helicopter evacuations ? is remembered as the final day of the Vietnam War, March 29 marks an anniversary that holds greater meaning for many who fought, protested or otherwise lived the war. (AP Photo/Charles Harrity, File)

Marine veteran Harry Prestanski, 65, poses outside his home next to U.S. Marine Corps flag, Thursday, March 28, 2013, in West Chester, Ohio. Prestanski served 16 months as a Marine in the Vietnamese War and remembers having to celebrate his 21st birthday there. (AP Photo/Al Behrman)

Former North Vietnamese prisoner of war James H. Warner poses in Boonsboro, Md., on Thursday, March 28, 2013, the eve of the 40th anniversary of the withdrawal of the last U.S. combat troops from Vietnam. Warner, 72, of nearby Rohrersville, Md., says his 5 1/2 years of forced labor and interrogation reinforced his conviction that the United States was right to confront the spread of communism. (AP Photo/David Dishneau)

In this April 2, 1973 photo, President Richard Nixon and South Vietnamese President Nguyen Van Thieu are in profile as they listen to national anthems during arrival ceremonies for Thieu at the Western White House in San Clemente, Calif. As the last U.S. combat troops left Vietnam 40 years ago, angry protesters still awaited them at home. North Vietnamese soldiers took heart from their foes' departure, and South Vietnamese who had helped the Americans feared for the future. While the fall of Saigon two years later ? with its indelible images of frantic helicopter evacuations ? is remembered as the final day of the Vietnam War, Friday marks an anniversary that holds greater meaning for many who fought, protested or otherwise lived it. (AP Photo)

In this April 10, 1973 photo, Gen. Alexander M. Haig, center, is greeted by acting ambassador Charles Whitehouse, left, and another embassy official following Haig's arrival, in Saigon, the last stop in his whirlwind tour of Indochina. The trip was made at the behest of President Nixon. As the last U.S. combat troops left Vietnam 40 years ago, angry protesters still awaited them at home. North Vietnamese soldiers took heart from their foes' departure, and South Vietnamese who had helped the Americans feared for the future. While the fall of Saigon two years later ? with its indelible images of frantic helicopter evacuations ? is remembered as the final day of the Vietnam War, Friday marks an anniversary that holds greater meaning for many who fought, protested or otherwise lived it. (AP Photo/Neal Ulevich)

Forty years ago, soldiers returning from Vietnam were advised to change into civilian clothes on their flights home so that they wouldn't be accosted by angry protesters at the airport. For a Vietnamese businessman who helped the U.S. government, a rising sense of panic set in as the last combat troops left the country on March 29, 1973 and he began to contemplate what he'd do next. A young North Vietnamese soldier who heard about the withdrawal felt emboldened to continue his push on the battlefields of southern Vietnam.

While the fall of Saigon two years later ? with its indelible images of frantic helicopter evacuations ? is remembered as the final day of the Vietnam War, Friday marks an anniversary that holds greater meaning for many who fought, protested or otherwise lived the war. Since then, they've embarked on careers, raised families and in many cases counseled a younger generation emerging from two other faraway wars.

Many veterans are encouraged by changes they see. The U.S. has a volunteer military these days, not a draft, and the troops coming home aren't derided for their service. People know what PTSD stands for, and they're insisting that the government take care of soldiers suffering from it and other injuries from Iraq and Afghanistan.

Below are the stories of a few of the people who experienced a part of the Vietnam War firsthand.

___

Former Air Force Sgt. Howard Kern, who lives in central Ohio near Newark, spent a year in Vietnam before returning home in 1968.

He said that for a long time he refused to wear any service ribbons associating him with southeast Asia and he didn't even his tell his wife until a couple of years after they married that he had served in Vietnam. He said she was supportive of his war service and subsequent decision to go back to the Army to serve another 18 years.

Kern said that when he flew back from Vietnam with other service members, they were told to change out of uniform and into civilian clothes while they were still on the airplane to avoid the ire of protesters at the airport.

"What stands out most about everything is that before I went and after I got back, the news media only showed the bad things the military was doing over there and the body counts," said Kern, now 66. "A lot of combat troops would give their c rations to Vietnamese children, but you never saw anything about that ? you never saw all the good that GIs did over there."

Kern, an administrative assistant at the Licking County Veterans' Service Commission, said the public's attitude is a lot better toward veterans coming home for Iraq and Afghanistan ? something the attributes in part to Vietnam veterans.

"We're the ones that greet these soldiers at the airports. We're the ones who help with parades and stand alongside the road when they come back and applaud them and salute them," he said.

He said that while the public "might condemn war today, they don't condemn the warriors."

"I think the way the public is treating these kids today is a great thing," Kern said. "I wish they had treated us that way."

But he still worries about the toll that multiple tours can take on service members.

"When we went over there, you came home when your tour was over and didn't go back unless you volunteered. They are sending GIs back now maybe five or seven times, and that's way too much for a combat veteran," he said.

He remembers feeling glad when the last troops left Vietnam, but was sad to see Saigon fall two years later. "Vietnam was a very beautiful country, and I felt sorry for the people there," he said.

___

Tony Lam was 36 on the day the last U.S. combat troops left Vietnam. He was a young husband and father, but most importantly, he was a businessman and U.S. contractor furnishing dehydrated rice to South Vietnamese troops. He also ran a fish meal plant and a refrigerated shipping business that exported shrimp.

As Lam, now 76, watched American forces dwindle and then disappear, he felt a rising panic. His close association with the Americans was well-known and he needed to get out ? and get his family out ? or risk being tagged as a spy and thrown into a Communist prison. He watched as South Vietnamese commanders fled, leaving whole battalions without a leader.

"We had no chance of surviving under the Communist invasion there. We were very much worried about the safety of our family, the safety of other people," he said this week from his adopted home in Westminster, Calif.

But Lam wouldn't leave for nearly two more years after the last U.S. combat troops, driven to stay by his love of his country and his belief that Vietnam and its economy would recover.

When Lam did leave, on April 21, 1975, it was aboard a packed C-130 that departed just as Saigon was about to fall. He had already worked for 24 hours at the airport to get others out after seeing his wife and two young children off to safety in the Philippines.

"My associate told me, 'You'd better go. It's critical. You don't want to end up as a Communist prisoner.' He pushed me on the flight out. I got tears in my eyes once the flight took off and I looked down from the plane for the last time," Lam recalled. "No one talked to each other about how critical it was, but we all knew it."

Now, Lam lives in Southern California's Little Saigon, the largest concentration of Vietnamese outside of Vietnam.

In 1992, Lam made history by becoming the first Vietnamese-American to elected to public office in the U.S. and he went on to serve on the Westminster City Council for 10 years.

Looking back over four decades, Lam says he doesn't regret being forced out of his country and forging a new, American, life.

"I went from being an industrialist to pumping gas at a service station," said Lam, who now works as a consultant and owns a Lee's Sandwich franchise, a well-known Vietnamese chain.

"But thank God I am safe and sound and settled here with my six children and 15 grandchildren," he said. "I'm a happy man."

___

Wayne Reynolds' nightmares got worse this week with the approach of the anniversary of the U.S. troop withdrawal.

Reynolds, 66, spent a year working as an Army medic on an evacuation helicopter in 1968 and 1969. On days when the fighting was worst, his chopper would make four or five landings in combat zones to rush wounded troops to emergency hospitals.

The terror of those missions comes back to him at night, along with images of the blood that was everywhere. The dreams are worst when he spends the most time thinking about Vietnam, like around anniversaries.

"I saw a lot of people die," said Reynolds.

Today, Reynolds lives in Athens, Ala., after a career that included stints as a public school superintendent and, most recently, a registered nurse. He is serving his 13th year as the Alabama president of the Vietnam Veterans of America, and he also has served on the group's national board as treasurer.

Like many who came home from the war, Reynolds is haunted by the fact he survived Vietnam when thousands more didn't. Encountering war protesters after returning home made the readjustment to civilian life more difficult.

"I was literally spat on in Chicago in the airport," he said. "No one spoke out in my favor."

Reynolds said the lingering survivor's guilt and the rude reception back home are the main reasons he spends much of his time now working with veteran's groups to help others obtain medical benefits. He also acts as an advocate on veterans' issues, a role that landed him a spot on the program at a 40th anniversary ceremony planned for Friday in Huntsville, Ala.

It took a long time for Reynolds to acknowledge his past, though. For years after the war, Reynolds said, he didn't include his Vietnam service on his resume and rarely discussed it with anyone.

"A lot of that I blocked out of my memory. I almost never talk about my Vietnam experience other than to say, 'I was there,' even to my family," he said.

___

A former North Vietnamese soldier, Ho Van Minh heard about the American combat troop withdrawal during a weekly meeting with his commanders in the battlefields of southern Vietnam.

The news gave the northern forces fresh hope of victory, but the worst of the war was still to come for Minh: The 77-year-old lost his right leg to a land mine while advancing on Saigon, just a month before that city fell.

"The news of the withdrawal gave us more strength to fight," Minh said Thursday, after touring a museum in the capital, Hanoi, devoted to the Vietnamese victory and home to captured American tanks and destroyed aircraft.

"The U.S. left behind a weak South Vietnam army. Our spirits was so high and we all believed that Saigon would be liberated soon," he said.

Minh, who was on a two-week tour of northern Vietnam with other veterans, said he bears no ill will to the American soldiers even though much of the country was destroyed and an estimated 3 million Vietnamese died.

If he met an American veteran now he says, "I would not feel angry; instead I would extend my sympathy to them because they were sent to fight in Vietnam against their will."

But on his actions, he has no regrets. "If someone comes to destroy your house, you have to stand up to fight."

___

Two weeks before the last U.S. troops left Vietnam, Marine Corps Capt. James H. Warner was freed from North Vietnamese confinement after nearly 5 1/2 years as a prisoner of war. He said those years of forced labor and interrogation reinforced his conviction that the United States was right to confront the spread of communism.

The past 40 years have proven that free enterprise is the key to prosperity, Warner said in an interview Thursday at a coffee shop near his home in Rohrersville, Md., about 60 miles from Washington. He said American ideals ultimately prevailed, even if our methods weren't as effective as they could have been.

"China has ditched socialism and gone in favor of improving their economy, and the same with Vietnam. The Berlin Wall is gone. So essentially, we won," he said. "We could have won faster if we had been a little more aggressive about pushing our ideas instead of just fighting."

Warner, 72, was the avionics officer in a Marine Corps attack squadron when his fighter plane was shot down north of the Demilitarized Zone in October 1967.

He said the communist-made goods he was issued as a prisoner, including razor blades and East German-made shovels, were inferior products that bolstered his resolve.

"It was worth it," he said.

A native of Ypsilanti, Mich., Warner went on to a career in law in government service. He is a member of the Republican Central Committee of Washington County, Md.

___

Denis Gray witnessed the Vietnam War twice ? as an Army captain stationed in Saigon from 1970 to 1971 for a U.S. military intelligence unit, and again as a reporter at the start of a 40-year career with the AP.

"Saigon in 1970-71 was full of American soldiers. It had a certain kind of vibe. There were the usual clubs, and the bars were going wild," Gray recalled. "Some parts of the city were very, very Americanized."

Gray's unit was helping to prepare for the troop pullout by turning over supplies and projects to the South Vietnamese during a period that Washington viewed as the final phase of the war. But morale among soldiers was low, reinforced by a feeling that the U.S. was leaving without finishing its job.

"Personally, I came to Vietnam and the military wanting to believe that I was in a ? maybe not a just war but a ? war that might have to be fought," Gray said. "Toward the end of it, myself and most of my fellow officers, and the men we were commanding didn't quite believe that ... so that made the situation really complex."

After his one-year service in Saigon ended in 1971, Gray returned home to Connecticut and got a job with the AP in Albany, N.Y. But he was soon posted to Indochina, and returned to Saigon in August 1973 ? four months after the U.S. troops withdrew from Vietnam ? to discover a different city.

"The aggressiveness that militaries bring to any place they go ? that was all gone," he said. A small American presence remained, mostly diplomats, advisers and aid workers but the bulk of troops had left. The war between U.S.-allied South Vietnam and communist North Vietnam was continuing, and it was still two years before the fall of Saigon to the communist forces.

"There was certainly no panic or chaos ? that came much later in '74, '75. But certainly it was a city with a lot of anxiety in it."

The Vietnam War was the first of many wars Gray witnessed. As AP's Bangkok bureau chief for more than 30 years, Gray has covered wars in Cambodia, Iraq, Afghanistan, Somalia, Rwanda, Kosovo, and "many, many insurgencies along the way."

"I don't love war, I hate it," Gray said. "(But) when there have been other conflicts, I've been asked to go. So, it was definitely the shaping event of my professional life."

___

Harry Prestanski, 65, of West Chester, Ohio, served 16 months as a Marine in Vietnam and remembers having to celebrate his 21st birthday there. He is now retired from a career in public relations and spends a lot of time as an advocate for veterans, speaking to various organizations and trying to help veterans who are looking for jobs.

"The one thing I would tell those coming back today is to seek out other veterans and share their experiences," he said. "There are so many who will work with veterans and try to help them ? so many opportunities that weren't there when we came back."

He says that even though the recent wars are different in some ways from Vietnam, those serving in any war go through some of the same experiences.

"One of the most difficult things I ever had to do was to sit down with the mother of a friend of mine who didn't come back and try to console her while outside her office there were people protesting the Vietnam War," Prestanski said.

He said the public's response to veterans is not what it was 40 years ago and credits Vietnam veterans for helping with that.

"When we served, we were viewed as part of the problem," he said. "One thing about Vietnam veterans is that ? almost to the man ? we want to make sure that never happens to those serving today. We welcome them back and go out of our way to airports to wish them well when they leave."

He said some of the positive things that came out of his war service were the leadership skills and confidence he gained that helped him when he came back.

"I felt like I could take on the world," he said.

___

Flaccus reported from Los Angeles and Cornwell reported from Cincinnati. Also contributing to this report were Associated Press writers Chris Brummitt in Hanoi, David Dishneau in Hagerstown, Md., and Jay Reeves in Birmingham, Ala.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-03-28-Vietnam%20Withdrawal-Anniversary/id-1b24064db12b4637b3970e45dd43e7cb

polling place washington post comedy central philadelphia eagles obamacare Todd Akin Register To Vote

Pope urges Catholic priests to help poor, shun careerism

By Philip Pullella

VATICAN CITY (Reuters) - Beginning a busy program of Easter events, Pope Francis on Thursday urged Catholic priests to devote themselves to helping the poor and suffering instead of worrying about careers as Church "managers".

Francis' homily at his first Holy Thursday service as Roman Catholic leader was the latest sign since his surprise election two weeks ago of his determination that the 1.2 billion-member Church should be closer to the poor.

"We need to go out, then, in order to experience our own anointing (as priests) ... to the outskirts where there is suffering, bloodshed, blindness that longs for sight, and prisoners in thrall to many evil masters," he said during a Mass in St. Peter's Basilica.

The 76-year-old former Cardinal Jorge Bergoglio of Argentina has inherited a Vatican rocked by a scandal in which documents leaked to the media spoke of alleged corruption in its administration and depicted prelates as fighting among themselves to advance their careers.

At the Mass, the start of four days of hectic activities leading up to Easter this Sunday, Francis said priests should not get bogged down in "introspection" but step outside of themselves and concentrate on those who need their help.

"Those who do not go out of themselves, instead of being mediators, gradually become intermediaries, managers. We know the difference: the intermediary, the manager ... doesn't put his own skin and his own heart on the line, he never hears a warm, heartfelt word of thanks," he said.

In the next few weeks, Francis is expected to start making changes in the Curia, the central bureaucracy that was at the heart of the so-called "Vatileaks" scandal.

The new pope delivered his appeal for priests to live simply and closest to the needy on the day when the Catholic Church commemorates when Jesus founded the priesthood at the Last Supper on the night before he died.

Speaking to about 1,600 priests from Rome who attended the Mass, he said those who did not live in humility close to the people risked becoming "collectors of antiques or novelties - instead of being shepherds living with 'the smell of the sheep'"

The pope took the name Francis after St. Francis of Assisi, who is associated with austerity and helping the poor. The new pontiff has already set a clear tone for a humbler papacy and Church.

Later on Thursday, he will wash and kiss the feet of 12 young inmates at a youth prison on the outskirts of Rome, at a Holy Thursday ceremony commemorating Jesus's gesture of humility towards his apostles on the night before he died.

All popes in living memory have held the service either in St. Peter's or the Basilica of St. John in Lateran, which is the pope's cathedral church in his capacity as bishop of Rome.

The four days leading up to Easter are the most hectic in the Church's liturgical calendar.

On Friday Francis will preside at two Good Friday services including the traditional "Via Crucis" (Way of the Cross) procession around the ancient Colosseum in Rome.

He celebrates an Easter eve service on Saturday night and on Easter Sunday, the most important day in the Church's liturgical calendar, he will deliver his first "Urbi et Orbi" (to the city and the world) message to a large crowd in St. Peter's Square.

(Reporting By Philip Pullella; editing by Barry Moody)

Source: http://news.yahoo.com/pope-urges-catholic-priests-help-poor-shun-careerism-112315330.html

senior bowl norovirus Coachella 2013 Eclampsia Kendrick Lamar JJ Abrams New Orleans Pelicans

Fuel may be the world?s tiniest phone backup battery

The Fuel?backup power source is a Kickstarter project from Devotec Industries, a maker of backup batteries and Bluetooth speakers. ?(Is it just me, or does it seem like a lot of companies are looking to expand their product lines through crowd-funding projects lately?) ?The Fuel is a 220mAh emergency power source for any phone that [...]

Source: http://the-gadgeteer.com/2013/03/27/fuel-may-be-the-worlds-tiniest-phone-backup-battery/

ben and jerrys free cone day tornado in dallas texas the island president the maldives harper lee mega millions numbers the fray

Ashley Judd Won't Run for Senate in Kentucky

gty ashley judd ll 130327 wblog Ashley Judd Wont Run for Senate in Kentuckyashley judd

ABC News' Michael Falcone and Shushannah Walshe report:

After months of flirtation, actress Ashley Judd announced on Wednesday that she will not pursue a Senate bid against Senate Minority Leader Mitch McConnell, R-Ky.

She made the announcement in a series of tweets late Wednesday afternoon:

"After serious and thorough contemplation, I realize that my responsibilities & energy at this time need to be focused on my family. Regretfully, I am currently unable to consider a campaign for the Senate. I have spoken to so many Kentuckians over these last few months who expressed their desire for a fighter for the people & new leader. While that won't be me at this time, I will continue to work as hard as I can to ensure the needs of Kentucky families are met by returning this Senate seat to whom it rightfully belongs: the people & their needs, dreams, and great potential. Thanks for even considering me as that person & know how much I love our Commonwealth. Thank you!"

A source familiar with Judd's decision-making process said the news that Kentucky Secretary of State Allison Lundergan Grimes has also been considering a Senate run "gave her the space to really make a decision and decide what was best for her."

The source said Judd has known she was not running for "the past few days" but only decided to make her decision public on Wednesday.

As late as last Friday, Judd was still hinting at a run, referring to her potential run against McConnell and foreshadowing what she presumed would be a barrage of attack ads from his campaign. She told a conference audience in Cincinnati that she used to be averse to hearing criticism, which she said was ironic because she was "about to get $40 million worth of it."

In the same speech, she also joked that her mother, country star Naomi Judd, couldn't wait to turn her garage into campaign headquarters.

Rep. John Yarmuth, D-Ky., who was one of Judd's most vocal boosters, issued a statement on Wednesday through his spokesman.

RELATED: Will Ashley Judd Run in 2016?

"Congressman Yarmuth has said all along he would be surprised if Ashley Judd did not make this race, and he's certainly surprised. While he is disappointed because he believed Judd would be a strong candidate, he's confident that a candidate just as strong will emerge to take on Sen. McConnell, who is the least popular senator in the country," Yarmuth spokesman Stephen George said in a statement to ABC News.

George added that Judd and Yarmuth spoke earlier this week, a conversation in which she did "express some reservations about the race," but he added they had been speaking throughout the process and that was not unusual."

Judd's interest in the race spurred widespread national attention, including from former President Bill Clinton, who spoke to both Judd and Grimes about the seat, encouraging them both to take a hard look at the race.

ABC News reported last week that Clinton encouraged Judd to enter the race and promised he would help her, according to several Kentucky political sources. That conversation happened sometime between the November election and President Barack Obama's second inauguration.

Earlier this month Clinton also met with Grimes after he spoke at an event for former Kentucky Sen. Wendell Ford in Owensboro, Ky., according to multiple political sources in the state. Clinton encouraged Grimes to consider taking on McConnell, adding as he did with Judd that he would support her.

Even with the Hollywood actress's star power, a campaign against McConnell, a political institution in Kentucky, would have been an uphill battle. Shortly after Judd's announcement, the National Republican Senatorial Committee in Washington circulated a list of 10 Kentucky Democrats who have all passed on a chance to take on McConnell, including the state's Democratic governor, Steve Beshear.

"The hollow DSCC spin that Kentucky will be competitive still hasn't made its way to the Bluegrass State," NRSC spokesman Brad Dayspring said in a statement. Citing the list of 10 Democratic names, Dayspring added, "Perhaps number eleven might be a lucky charm?"

Also Read

Source: http://news.yahoo.com/ashley-judd-wont-run-senate-kentucky-212022710--abc-news-politics.html

kingdom of heaven national enquirer whitney houston arizona republican debate arizona debate enquirer national inquirer knicks vs heat

Wednesday, March 27, 2013

Hunger-spiking neurons could help control autoimmune diseases

Mar. 25, 2013 ? Neurons that control hunger in the central nervous system also regulate immune cell functions, implicating eating behavior as a defense against infections and autoimmune disease development, Yale School of Medicine researchers have found in a new study published in the Proceedings of the National Academy of Sciences (PNAS).

Autoimmune diseases have been on a steady rise in the United States. These illnesses develop when the body's immune system turns on itself and begins attacking its own tissues. The interactions between different kinds of T cells are at the heart of fighting infections, but they have also been linked to autoimmune disorders.

"We've found that if appetite-promoting AgRP neurons are chronically suppressed, leading to decreased appetite and a leaner body weight, T cells are more likely to promote inflammation-like processes enabling autoimmune responses that could lead to diseases like multiple sclerosis," said lead author Tamas Horvath, the Jean and David W. Wallace Professor of Biomedical Research and chair of comparative medicine at Yale School of Medicine.

"If we can control this mechanism by adjusting eating behavior and the kinds of food consumed, it could lead to new avenues for treating autoimmune diseases," he added.

Horvath and his research team conducted their study in two sets of transgenic mice. In one set, they knocked out Sirt1, a signaling molecule that controls the hunger-promoting neuron AgRP in the hypothalamus. These Sirt1-deficient mice had decreased regulatory T cell function and enhanced effector T cell activity, leading to their increased vulnerability in an animal model of multiple sclerosis.

"This study highlights the important regulatory role of the neurons that control appetite in peripheral immune functions," said Horvath. "AgRP neurons represent an important site of action for the body's immune responses."

The team's data support the idea that achieving weight loss through the use of drugs that promote a feeling of fullness "could have unwanted effects on the spread of autoimmune disorders," he notes.

Other authors on the study include Giuseppe Matarese, Claudio Procaccini, Ciro Menale, Jae Geun Kim, Jung Dae Kim, Sabrina Diano, Nadia Diano, Veronica De Rosa, and Marcelo O. Dietrich.

The study was funded by grants from the NIH Director's Pioneer Award.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Yale University. The original article was written by Karen N. Peart.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/k95LXvvaaiY/130325160516.htm

easter bunny navy jet crash virginia beach isiah thomas easter recipes live free or die hard carlos pena amanda bynes arrested